Evaluation of Renal Ischemia–Reperfusion Injury Using Optical Coherence Tomography Based on Fractal Dimension

Renal ischemia–reperfusion (IR) is inevitable in partial nephrectomy and kidney transplantation. Acute tubular necrosis (ATN) induced by renal IR causes the loss of functional units kidney, pathologically presenting as nonhomogeneous distribution normal uriniferous tubules usually used to characterize activity. Optical coherence tomography (OCT) has been proven have ability image microstructure vivo real time. However, a fast analysis method needed for clinical application purpose. In this work, new assessing injury was developed using fractal-dimension-based texture OCT image. Thirty-five Wistar rats were divided into seven groups ischemia–reperfusion: control various ischemia-time groups. A time series 3D images obtained. We calculated fractal dimension (FD) en face found that value increased gradually finally became stable after 90 min reperfusion. The long-ischemia-time group smaller than short-ischemia-time group. FD highly responsive injury. proposed promising diagnostic application.